Structure of the formin Cdc12 bound to the barbed end of phalloidin-stabilized F-actin.
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8rtt
Q-score: 0.444
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
To Be Published
- Phosphate ion (94 Da, Ligand)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dimeric fh2 domain of s. pombe cdc12 (Complex from Schizosaccharomyces pombe)
- Phalloidin. (Complex from Amanita phalloides)
- Phalloidin (808 Da, Protein from Amanita phalloides)
- Cell division control protein 12 (48 kDa, Protein from Schizosaccharomyces pombe)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin filament (Complex from Homo sapiens)
- Complex of the dimeric fh2 domain of s. pombe cdc12 bound to the barbed end of phalloidin stabilized f-actin. (Complex)
Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 8pqz
Q-score: 0.284
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ DOI: doi:10.1126/science.adk8544 Pubmed: 38547289 ]
- Magnesium ion (24 Da, Ligand)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-a1/a2 motor domains bound to lis1 (Complex from Homo sapiens)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
Late alpha-Synuclein fibril structure from liquid-liquid phase separations.
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ri9
Q-score: 0.498
Chen SW, Barritt JD, Cascella R, Bigi A, Cecchi C, Banchelli M, Gallo A, Jarvis JA, Chiti F, Dobson CM, Fusco G, De Simone A
J Am Chem Soc (2024) 146 pp. 10537-10549 [ DOI: doi:10.1021/jacs.3c14703 Pubmed: 38567991 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Fibrillar complex of alpha-synuclein (Complex from Homo sapiens)
Alpha-synuclein amyloid fibrils
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8rqm
Q-score: 0.477
Monistrol J, Beton JG, Johnston EC, Saibil HR
bioRxiv (2024) [ DOI: doi:10.1101/2024.01.25.577078 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Alpha-synuclein amyloid fibril
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8rrr
Q-score: 0.531
Monistrol J, Beton JG, Johnston EC, Saibil HR
bioRxiv (2024) [ DOI: doi:10.1101/2024.01.25.577078 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Apo KIF20A[1-565] class-2 in complex with a microtubule
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8f18
Q-score: 0.404
Ranaivoson FM, Crozet V, Benoit MPMH, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, El Marjou A, Miserey-Lenkei S, Asenjo AB, Sosa H, Schmidt CF, Rosenfeld SS, Houdusse A
Open Biol (2023) 13 pp. 230122-230122 [ DOI: doi:10.1098/rsob.230122 Pubmed: 37726093 ]
- Taxol (853 Da, Ligand)
- Kinesin-like protein kif20a (64 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 15r microtubule (Cellular component from Sus scrofa)
- Tubulin alpha-1b chain (50 kDa, Protein from Sus scrofa)
- Tubulin beta-2b chain (49 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kif20a[1-565] apo (Complex from Mus musculus)
- Kif20a[1-565] apo in complex with a microtubule - class 2 (Complex)
Apo KIF20A[1-565] class-1 in complex with a microtubule
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8f1a
Q-score: 0.463
Ranaivoson FM, Crozet V, Benoit MPMH, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, El Marjou A, Miserey-Lenkei S, Asenjo AB, Sosa H, Schmidt CF, Rosenfeld SS, Houdusse A
Open Biol (2023) 13 pp. 230122-230122 [ DOI: doi:10.1098/rsob.230122 Pubmed: 37726093 ]
- Taxol (853 Da, Ligand)
- Kinesin-like protein kif20a (64 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 15r microtubule (Cellular component from Sus scrofa)
- Tubulin alpha-1b chain (50 kDa, Protein from Sus scrofa)
- Tubulin beta-2b chain (49 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kif20a[1-565] apo (Complex from Mus musculus)
- Kif20a[1-565] apo in complex with a microtubule (Complex)
Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the R183W mutation
Resolution: 2.28 Å
EM Method: Single-particle
Fitted PDBs: 8oi8
Q-score: 0.679
Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P, Raunser S
Nat Struct Mol Biol (2023) 30 pp. 1774-1785 [ Pubmed: 37749275 DOI: doi:10.1038/s41594-023-01101-9 ]
- Water (18 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Actin filament harboring the r183w mutation. (Complex from Homo sapiens)
- Actin, cytoplasmic 1 (41 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8oid
Q-score: 0.681
Oosterheert W, Blanc FEC, Roy A, Belyy A, Sanders MB, Hofnagel O, Hummer G, Bieling P, Raunser S
Nat Struct Mol Biol (2023) 30 pp. 1774-1785 [ Pubmed: 37749275 DOI: doi:10.1038/s41594-023-01101-9 ]
- Water (18 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, cytoplasmic 1, n-terminally processed (41 kDa, Protein from Homo sapiens)
- Actin filament harboring the n111s mutation. (Complex from Homo sapiens)
Structure of recombinantly assembled A53E alpha-synuclein fibrils
Resolution: 3.38 Å
EM Method: Helical reconstruction
Fitted PDBs: 7uak
Q-score: 0.463
Sun C, Zhou K, DePaola IV P, Shin WS, Hillyer T, Sawaya MR, Zhu R, Peng C, Zhou ZH, Jiang L
J Biol Chem (2023) 299 pp. 104566-104566 [ Pubmed: 36871760 DOI: doi:10.1016/j.jbc.2023.104566 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein a53e mutant (59 MDa, Cellular component from Homo sapiens)